KEY POINTS Preterm children are at increased risk of cerebral palsy compared with term-born infants. Early diagnosis of cerebral palsy is possible within the first 6 months of life using a combination of clinical history, neuroimaging, and physical examination. Infants with cerebral palsy should be referred for cerebral palsy–specific early intervention, which includes task-specific training, environmental enrichment, and parental support. Infants with cerebral palsy should be screened for comorbidities including pain, epilepsy, sleep disorders, visual impairment, and hearing impairments to maximize outcomes.